In the United States, immigrant entrepreneurs start almost one third of all new businesses. However, many immigrant entrepreneurs lack the knowledge or expertise to evolve their businesses beyond the ethnic enclave where their businesses are located. This multiple case study captured the strategies used by five Latino immigrant business owners who successfully expanded their business beyond their ethnic enclave. The conceptual framework for this study was dynamic capabilities theory. Data were collected from interviews, company documents, and observations of the operation of businesses and owners. Member checking and transcript reviews were used to enhance the reliability and credibility of the data. Miles, Huberman, and Saldana’s data analysis method was used to identify six themes that yielded three possible strategies to help Latino immigrant business owners expand outside of their enclave: (a) adopt a multicultural hybridism model changing the internal makeup of the employee base to include more interethnic labor and managerial resources; (b) achieve language and cultural proficiency of the host community; and (c) seek and nurture professional development and mentorship relationships to obtain access to advice, opportunities, and financial resources. Also noted was the importance of individual readiness to seize opportunities and being tenacious in their business efforts. The study findings may contribute to positive social change because strategies that help immigrant entrepreneurs succeed have benefits that extend beyond their immediate family to the broader communities in which they operate by increasing job creation, wealth accumulation, and the development of society.