Title

Cognitive Performance and Mood Changes in the Post-thyroidectomy Patient Treated with T4 versus T4+T3

Authors

Lorena Likaj, Walden University

Files

Description

This study investigated changes in cognition and mood in the post-thyroidectomy patient. Specifically, this study investigates changes in cognition and mood, when the patient has been returned to normal, laboratory serum thyroid-stimulating hormone (TSH) reference levels, following conventional thyroid hormone replacement therapies with levothyroxine (T4) alone. Findings reveal a distinct, small, and clinically significant subgroup of post-thyroidectomy patients (10–15%) who continue to experience impaired cognition and mood, even when routinely measured serum TSH levels have been returned to normal levels. Findings are discussed within a conceptual matrix emphasizing the differential role of deiodinase enzymes required for conversion of T4 to T3 within the brain (Type II), compared to T4 to T3 conversion completed in peripheral tissues.

Publication Date

2017

City

National Harbor, MD

Keywords

Research Symposium

Disciplines

Medicine and Health Sciences