Date of Conferral

10-31-2025

Date of Award

October 2025

Degree

Doctor of Nursing Practice (DNP)

School

Nursing

Advisor

Barbara Barrett

Abstract

This Doctor of Nursing Practice (DNP) project addressed the critical gap in timely and accurate diagnosis and treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a post-infectious neuroinflammatory condition presenting with abrupt obsessive-compulsive behaviors, motor tics, and emotional dysregulation. These diagnostic delays contribute to prolonged morbidity and underscore the need for standardized, evidence-based nursing interventions. The purpose of this project was to develop and validate an evidence-based clinical practice guideline (CPG) to improve the recognition, assessment, and management of PANDAS within outpatient pediatric mental health settings. A systematic review of 12 peer-reviewed studies was conducted using the Johns Hopkins Evidence-Based Practice Model to appraise and synthesize the literature. The resulting CPG was evaluated by an interdisciplinary panel of six psychiatric and medical professionals using the AGREE II instrument. Findings revealed consistently high mean ratings (6–7) across all AGREE II domains, demonstrating strong endorsement for methodological rigor, clarity, and applicability. Qualitative feedback characterized the guideline as clear, evidence-based, and clinically relevant. The expert panel unanimously approved the CPG and recommended its broader dissemination. Implementation of this CPG is expected to enhance diagnostic accuracy, promote equitable and evidence-informed care, and strengthen the nursing role in interdisciplinary pediatric practice. Beyond clinical implications, the project advances positive social change by reducing stigma, promoting inclusion, and improving outcomes for children affected by PANDAS.

Download

Included in

Psychology Commons

Share

 
COinS