Date of Conferral
6-1992
Degree
Ph.D.
School
Health Sciences
Advisor
Dr. Fred Roland
Abstract
Antimicrobial resistance is becoming an increasingly serious problem accompanied by relatively few studies examining the relationship between use and resistance. The present study undertakes a twenty year analysis of antimicrobial production and factors affecting antimicrobial use for a particular microorganism (Stp. faecalis)/antimicrobial agent (Cephalothin) combination. The period is inclusive of the market introduction of the agent and considerate of prescribing practices to the present time. The accumulated data reveal that there is indeed a relationship between total drug availability (medicinal, agricultural) and increased antimicrobial resistance. The data also suggest that national (or global) use changes would likely have a long term beneficial effect on the deteriorating circumstances surrounding microbial resistance to antimicrobial chemotherapeutic agents The methodology utilized includes analysis of primary historical data and graphical representation of indices derived from these data. A literature review examines the impact on antimicrobial resistance by historical duration of use, various mechanisms of resistance, non-medical uses of antimicrobial agents and clinical misuse.
Recommended Citation
Griffith, James T., "The Influence of Antimicrobial use on Bacterial Resistance" (1992). Walden Dissertations and Doctoral Studies. 1395.
https://scholarworks.waldenu.edu/dissertations/1395
Included in
Bacteria Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Pathology Commons, Other Medical Sciences Commons, Other Medicine and Health Sciences Commons