Title

Widespread Skin Necrosis Secondary to Gemcitabine Therapy

Document Type

Article

Publication Date

2018

Originally Published In

Journal of Drugs in Dermatology

Volume Number

17

Issue Number

5

Page Numbers

582-585

Abstract

Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. This is the first reported case of a TEN-like reaction subsequent to gemcitabine treatment.

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