This research explored strategies used by some healthcare leaders to address substance abusing and impaired healthcare professionals. The conceptual framework for this qualitative case study was the concept of due diligence. Data were collected from 40 managers and supervisors, 3 executives, and company documents, and analyzed to reveal elements of a comprehensive strategy. A effective comprehensive strategy consists of policies that address the causes, the short term and long term aspects, and both the ethical and legal aspects. Policies and procedures are equally applied, are easily accessible, are well communicated, are supported by training, provides positive encouragement. provides a path for recovery, includes audits to ensure compliance and provides for organizational reviews to determine the need for updating. Leaders who implement a such a strategy to address substance abuse among healthcare professionals can create positive social change by ensuring a safer environment for patients, employees and their communities they serve.