Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease

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JAMA Dermatology


Chronic graft-vs-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. The skin is the most commonly involved site and may present with a broad range of inflammatory and fibrotic manifestations that add to the complexity of diagnosis and management in patients with skin of color.1 Subtle erythema may be difficult to discern because of background skin pigmentation. In addition, current validated physician-reported and patient-reported cGVHD outcome measures offer limited insight into the effect of cGVHD-associated dyspigmentation, which may be of greater significance in patients with skin of color. This study explores the breadth and influence of cGVHD in a natural history cohort of patients with skin of color.