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Asian Indian women have a higher prevalence of cardio-metabolic diseases compared to women from other ethnicities and Asian Indian men in the United States. This is due to the lower level of physical activity behaviors among this population. The purpose of this study was to explore the perceived barriers to physical activity among Asian Indian women living in the United States. The theoretical framework that guided this study was Bandura’s social cognitive theory and the research design used was qualitative ethnographic approach. Participants were recruited from 2 Christian churches in Southern California using purposive and snowballing sampling strategies. Fifteen participants were selected for the study and 2 focus group interviews were conducted to collect the data. The data analysis was done using NVivo 12 plus software, and the information collected was coded and categorized into themes. Consistent with social cognitive theory, the findings of the study revealed a reciprocal relationship among personal, social, and environmental barriers to physical activity among Asian Indian women living in the United States. The study contributes to social change by providing an understanding of the barriers to assist healthcare providers when developing culturally sensitive interventions for Asian Indian women to improve their level of physical activity and reduce the risk of cardiometabolic disorders.