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Nurse educators make decisions regarding the inclusion or exclusion of non-nursing courses in a curriculum. The current literature lacks research regarding which courses have the most impact on first-time nursing licensing examination pass-rates. The purpose of this quasi-experimental study was to investigate if there is a specific combination of courses that enhance first-time licensing examination pass-rates, using 161 randomly selected accredited associate degree nursing programs. General systems theory applied to nursing education was the framework for the study. ANOVA and independent t-tests were used to address the questions of non-nursing courses or discipline-specific set of non-nursing courses' impact on first-time licensure pass-rates. The ANOVA and independent t-tests analyses did not yield any significant non-nursing courses or discipline-specific sets of non-nursing courses. The findings indicate that non-nursing courses are not a significant subsystem in nursing education when the sole outcome used is NCLEX-RN pass-rates. Nursing faculty can use the results of this study as evidence that the inclusion or exclusion of one non-nursing course over another will likely not be detrimental to their program. This study can lead to positive social change through increasing the evidence-based knowledge from which faculty can base their curriculum.