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The demanding work environments of professional nurses often contribute to high levels of stress that impact their professional practice and well-being. Although there is a significant amount of research regarding stress and absenteeism, a gap in the literature exists about the effects of holistic coping strategies on nurses' perceived stress and absenteeism. Based on the biopsychosocial model, the purpose of this quantitative study was to investigate effects of holistic coping strategies on perceived stress and absenteeism in 128 hospital nurses. An online cross-sectional survey design used the Perceived Stress Scale-10 to measure nurses' perceptions of stress. The independent grouping variable was self-reported use of meditation, massage, or exercise. Absenteeism data were collected using nurses' attendance records provided by the hospital nursing administration office. Multiple linear regression analysis and t tests were significant for increased absenteeism with the use of meditation, but showed no change in absenteeism with massage or exercise. There was no significant relationship found between use of massage, meditation, or exercise, and perceived stress. Consideration of these findings may be of interest to hospital administrators in addressing perceived stress and absenteeism in nursing personnel. Positive social change is achieved for society, community, and the individual by preventing burnout and by addressing the financial and attendance issues related to nurse shortages in hospitals.