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Social determinants have impacted disease states. The purpose of this study was to determine the influence of social determinants on the incidence of tuberculosis over a 20-year period for the state of New Jersey to determine interventions that can be developed for the state. The epidemiological triad (host-agent-environment) served as the theoretical foundation for this study. A quantitative series of cross sectional analyses were performed using secondary data from a New Jersey Department of Health database on population tuberculosis incidence for the state. Categorical data analyses were used to describe the data. According to study results, certain social determinants; such as gender, substance abuse, residence, and place of birth; and the age of the patient had an impact on tuberculosis incidence trend at the state level. The social change implications for this project could be that identifying the factors that impact tuberculosis incidence may reduce and lead to more targeted interventions, which in turn, would help to reduce the different kind of burdens; such as financial, social, and emotional; associated with this disease on the community where it is occurring.