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Teaching science to students with special needs requires different approaches. The purpose of this study: to provide a formative program evaluation documenting students’ reactions to the use of animals as instructional tools for science. Students with disabilities were scoring lower than those students without disabilities. It was conjectured that delivering science in a hands-on environment using animals would increase student interest to learn science and provide an alternative and effective way to meet teaching standards in science and tap into students’ natural curiosity and interest in the world around them.