In investigating the determinants of survival of prostate cancer cohorts, characterization of the cohort in terms of competing underlying causes of death would be appropriate. Atherosclerotic heart disease, bronchitis, acute myocardial infarction, chronic obstructive pulmonary disease, atherosclerotic cardiovascular disease, and stroke were found to be the major causes of death among prostate cancer cohorts aside from prostate cancer. A population-based assessment of the codeterminants of mortality and a demographic and clinical determinant of prostate cancer survival was undertaken. Average survival time and survival curves of the various age categories were significantly different. The average survival time and survival curves of the different levels of grade and SEER summary stage were significantly different. On average, the regression coefficients of age categories, the different levels of grade, and SEER summary stages were significant predictors of survival for the prostate cancer cohorts studied. Clinical management of prostate cancer patients should consider the risk factors for the identified codeterminants of mortality among prostate cancer cohorts.